abstract：AIM:To determine the frequency, pattern and distribution of stromal keratin expression in phyllodes tumours if any, which may impact diagnostic approaches. METHODS:The clinicopathological features of 109 phyllodes tumours comprising 70 (64.2%) benign, 30 (27.5%) borderline and nine (8.3%) malignant grades were evaluat...

journal_title：Journal of clinical pathology

authors： Chia Y,Thike AA,Cheok PY,Yong-Zheng Chong L,Man-Kit Tse G,Tan PH

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Breast-conserving surgery currently focuses on improving margin clearance and excision volume, the main pathology report parameters for oncological and cosmetic outcomes. AIM:To quantitatively evaluate discrepancies in surgical and pathological estimates of breast specimen sizes, including the influence of ...

journal_title：Journal of clinical pathology

authors： Krekel NM,van Slooten HJ,Barbé E,de Lange de Klerk ES,Meijer S,van den Tol MP

更新日期：2012-03-01 00:00:00

abstract：:This 14th best practice review is the second of a pair that examines tumour marker requesting primary care situations. This review considers carbohydrate antigen 125, α-fetoprotein and human chorionic gonadotropin. It is presented in question-answer format, referenced for each question. The recommendations represent a...

journal_title：Journal of clinical pathology

authors： Cabrera-Abreu JC,Smellie WS,Bowley R,Shaw N

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:During the last decade, whole slide images (WSI) have been used in many areas of pathology such as teaching, research, digital archiving, teleconsultation and quality assurance testing. However, WSI have not regularly been used for routine diagnosis, because of the lack of validation studies. AIM:To test th...

journal_title：Journal of clinical pathology

authors： Al-Janabi S,Huisman A,Vink A,Leguit RJ,Offerhaus GJ,Ten Kate FJ,van Dijk MR,van Diest PJ

更新日期：2012-02-01 00:00:00

abstract：AIMS:Meticillin-resistant Staphylococcus aureus (MRSA) strains isolated in Tawam Hospital, a tertiary care hospital in the United Arab Emirates, were examined in order to understand the reasons for a doubling of its incidence between 2003 and 2008 while maintaining the same infection control measures. METHODS:All cons...

journal_title：Journal of clinical pathology

authors： Sonnevend Á,Blair I,Alkaabi M,Jumaa P,Al Haj M,Ghazawi A,Akawi N,Jouhar FS,Hamadeh MB,Pál T

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Modification of the spiral arteries with loss of the muscular vascular wall, invaded by the trophoblasts, represents the goal of the physiological vascular adaptation during human implantation. When physiological vascular changes do not occur, an unfavourable evolution of gestation may develop as suggested...

journal_title：Journal of clinical pathology

authors： Avagliano L,Bulfamante GP,Morabito A,Marconi AM

更新日期：2011-12-01 00:00:00

abstract：AIMS:To assess the significance of flat epithelial atypia (FEA) on core biopsy by evaluating the proportion of cases upgraded to in-situ and invasive carcinoma on further sampling with vacuum-assisted biopsy (VAB) or diagnostic surgical biopsy. METHODS:A retrospective analysis was performed of all core biopsies contai...

journal_title：Journal of clinical pathology

authors： Rajan S,Sharma N,Dall BJ,Shaaban AM

更新日期：2011-11-01 00:00:00

abstract：AIMS:Venous invasion (VI) is a known independent prognostic indicator of recurrence and survival in colorectal cancer. The guidelines of the Royal College of Pathologists (RCPath) state that, in a series of resections, extramural VI should be detected in at least 25% of specimens. However, there is widespread variabili...

journal_title：Journal of clinical pathology

authors： Messenger DE,Driman DK,McLeod RS,Riddell RH,Kirsch R

更新日期：2011-11-01 00:00:00

abstract：AIMS:The purpose of this study was to compare the DNA-methylation signature in classic chronic Philadelphia negative myeloproliferative neoplasms (MPN), polycythaemia vera (PV) and essential thrombocythaemia (ET), in order to obtain a global insight into DNA-methylation changes associated with these malignancies. METH...

journal_title：Journal of clinical pathology

authors： Barrio S,Gallardo M,Albizua E,Jimenez A,Rapado I,Ayala R,Gilsanz F,Martin-Subero JI,Martinez-Lopez J

更新日期：2011-11-01 00:00:00

abstract：AIMS:To investigate the expression of the placental cell-specific associated proteins in infantile haemangioma (IH). METHODS:Immunohistochemical staining was used to investigate the expression of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), human leucocyte antigen-G (HLA-G), cytokeratin 7 (CK7)...

journal_title：Journal of clinical pathology

authors： Itinteang T,Tan ST,Guthrie S,Tan CE,McIntyre BC,Brasch HD,Day DJ

更新日期：2011-10-01 00:00:00

abstract：AIMS:The signalling system of phosphoinositides (PIs) is involved in a number of cell and tissue functions including membrane trafficking, ion channel activity, cell cycle, apoptosis, differentiation and cell and tissue polarity. Recently, a role in cell migration was hypothesised for PI and related molecules including...

journal_title：Journal of clinical pathology

authors： Lo Vasco VR,Pacini L,Di Raimo T,D'arcangelo D,Businaro R

更新日期：2011-10-01 00:00:00

abstract：:Late-stage ovarian carcinoma is almost universally fatal. BRCA mutations are associated with an improved outcome and enhanced sensitivity to platinum chemotherapy, yet recurrence and platinum resistance remain a major problem and highly effective regimens following platinum failure do not yet exist. Here we report a r...

journal_title：Journal of clinical pathology

authors： Osher DJ,Kushner YB,Arseneau J,Foulkes WD

更新日期：2011-10-01 00:00:00

abstract：AIMS:To assess the clinical efficacy of diagnostic procedures for breast cancer at a teaching hospital using internal auditing tools and quality control measures. METHODS:A retrospective assessment of 500 patients who underwent core needle biopsy (wide-bore needle biopsy; WBN) of palpable or non-palpable breast nodes ...

journal_title：Journal of clinical pathology

authors： Verenhitach BD,Elias S,Patrocínio AC,Nazário AC,Waizberg A

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:Bone marrow aspiration and biopsy is an invasive procedure associated with morbidity and mortality risk. We compared a powered bone marrow aspiration and biopsy device to the traditional method by relatively assessing pain scores, procedure times, biopsy capture rates, quality of material retrieved, and sa...

journal_title：Journal of clinical pathology

authors： Swords RT,Anguita J,Higgins RA,Yunes AC,Naski M,Padmanabhan S,Kelly KR,Mahalingam D,Philbeck T,Miller L,Puga TA,Giles FJ,Kinney MC,Brenner AJ

更新日期：2011-09-01 00:00:00

abstract：AIMS:To audit the cellular expression of the innate antibacterial enzyme lysozyme in colonic biopsies from a cohort of patients having microscopic colitis (MC-collagenous colitis (CC) or lymphocytic colitis (LC)). Results were compared with those recorded in patients with inflammatory bowel disease (IBD) of the colon (...

journal_title：Journal of clinical pathology

authors： Rubio CA

更新日期：2011-06-01 00:00:00

abstract：AIMS:The aims of this study were (1) to determine the measurement accuracy of a widely used guaiac faecal occult blood test (gFOBT) compared with an immunochemical faecal occult blood test (iFOBT) during in vitro studies, including their analytical stability over time at ambient temperature and at 4°C; and (2) to compa...

journal_title：Journal of clinical pathology

authors： Lee CS,O'Gorman P,Walsh P,Qasim A,McNamara D,O'Morain CA,Boran GP

更新日期：2011-06-01 00:00:00

abstract：AIMS:To investigate how clinical microbiology laboratories should report and interpret mixed mould isolates including Aspergillus species from clinical samples and the criteria for susceptibility testing of the isolates. METHODS:Retrospectively collected data from our laboratory information system of moulds isolated b...

journal_title：Journal of clinical pathology

authors： Purcell J,McKenna J,Critten P,Denning DW,Hassan IA

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:The study sought to determine whether mast cell counts in endobronchial biopsies of large airways are related to mast cell counts in the small airways. METHODS:Lungs, obtained postmortem from 10 subjects who had died of non-respiratory causes, were fixed in inflation. Mast cell densities (cells/mm(3)), de...

journal_title：Journal of clinical pathology

authors： Carroll ML,Carroll NG,Gundersen HJ,James AL

更新日期：2011-05-01 00:00:00

abstract：:Inherited biochemical defects may present with acute life-threatening illness with a high mortality and morbidity. Some are treatable and have a good outcome with early appropriate intervention. However, because of their rarity, diagnosis is often delayed; they are not considered or investigated appropriately. This is...

journal_title：Journal of clinical pathology

authors： Cook P,Walker V

更新日期：2011-03-01 00:00:00

abstract：:In October 1859, 'The Queen of Hearts' was published by Wilkie Collins. This book is a collection of 10 short stories written by the protagonists (three retired brothers), in order to keep their niece (aka the queen of hearts) entertained, until the arrival of her fiancé-to-be. The second story of the book, titled 'Br...

journal_title：Journal of clinical pathology

authors： Fernandez-Flores A

更新日期：2011-02-01 00:00:00

abstract：:Performance of CHROMagar Acinetobacter was assessed for the selective isolation and identification of Acinetobacter baumannii. The medium was effective in suppressing the growth of other Gram-positive and Gram-negative species while the addition of KPC supplement ensured growth of only carbapenem resistant A baumannii...

journal_title：Journal of clinical pathology

authors： Wareham DW,Gordon NC

更新日期：2011-02-01 00:00:00

abstract：AIMS:The assessment of lymphatic vessel density (LVD) has been suggested as a tool to determine the metastatic risk of neoplasias. On this premise, the authors aimed to verify whether progression risk of stage I colorectal cancer may be related to LVD. The authors also evaluated and correlated vascular endothelial grow...

journal_title：Journal of clinical pathology

authors： Barresi V,Reggiani-Bonetti L,Di Gregorio C,De Leon MP,Barresi G

更新日期：2011-01-01 00:00:00

abstract：:Accurate diagnosis of Clostridium difficile infection (CDI) is essential for optimal treatment, prevention and control. There are two reference assays for CDI diagnosis: the cell cytotoxicity assay (CCTA) and toxigenic culture (TC). Importantly, these tests actually detect different targets: CCTA detects the presence ...

journal_title：Journal of clinical pathology

authors： Planche T,Wilcox M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Although Bulgaria has one of the highest rates of cervical cancer incidence and mortality in the EU, data on HPV type distribution are limited. AIM:To determine the prevalence of HPV types 16 and 18 in archival specimens from cervical cancer cases from Bulgaria. METHODS:A total of 145 formalin-fixed, paraf...

journal_title：Journal of clinical pathology

authors： Todorova I,Ganchev G,Shikova E

更新日期：2010-12-01 00:00:00

abstract：AIMS:To report the clinicopathological characteristics of patients with ocular adnexal marginal zone B cell lymphoma (MZBL) with IgG4-positive plasma cells. METHODS:114 biopsy samples of ocular adnexal MZBLs were analysed. MZBLs with IgG4-positive plasma cells were included when the IgG4:IgG ratio was >40% (IgG4-relat...

journal_title：Journal of clinical pathology

authors： Kubota T,Moritani S,Yoshino T,Nagai H,Terasaki H

更新日期：2010-12-01 00:00:00

abstract：AIM:To better understand the spectrum of primary lymphomas in the upper aerodigestive tract, a common site of extranodal lymphoma. MATERIALS AND METHODS:Lymphoma cases diagnosed at an institution in southern Taiwan from 1992 to 2007 were retrospectively studied with pathology and history review, immunohistochemistry, ...

journal_title：Journal of clinical pathology

authors： Chen SW,Chang ST,Lu CL,Hwang WS,Tsao CJ,Huang WT,Chang KY,Chuang SS

更新日期：2010-10-01 00:00:00

abstract：:Haemoglobin (Hb) Bonn is a newly described benign Hb variant that causes falsely depressed oxygen saturation as measured by pulse oximetry. It was found to be associated with mild haemolysis. Since its first report in a German family, no further cases have been documented in the literature. We report the first Chinese...

journal_title：Journal of clinical pathology

authors： So CC,Chan AY,Chow EY,Lin SY,Yip SF,Szeto SC,Chan LC

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Fatty liver disease (FLD), of either alcoholic (AFLD) or non-alcoholic (NAFLD) aetiologies, is characterised histologically by features that are lobulocentric that typically affect zone 3, in contrast with portal-based inflammation characteristics of other forms of chronic liver disease. AIM:The authors aim...

journal_title：Journal of clinical pathology

authors： Rakha EA,Adamson L,Bell E,Neal K,Ryder SD,Kaye PV,Aithal GP

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Intraoperative frozen section (FS) examination in thoracic surgery is a reliable method for diagnosis and staging of pulmonary lesions and provides a valuable guide in directing the extent of the ongoing surgical procedure. However, the contribution of touch preparation cytology (TPC) to FS diagnosis remains...

journal_title：Journal of clinical pathology

authors： Rakha EA,Haider A,Patil S,Fourtan H,Chaudry Z,Soomro IN

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The disorders associated with metabolic syndrome (MS) can lead to renal disease. IgA nephropathy is the most common form of glomerulonephritis, and many patients with this disorder progress to renal failure. AIMS:To identify the effect of MS on IgA nephropathy by retrospectively comparing patients who had I...

journal_title：Journal of clinical pathology

authors： Wang L,Zhang Y,Chen S,Chen J,Zhuang Y,Chen J

更新日期：2010-08-01 00:00:00

abstract：:The aim of this article is to provide knowledge of the origin of catecholamines and metabolites so that there can be an informed approach to the methods for biochemical screening for a possible phaeochromocytoma; The article includes a review of catecholamine and metadrenaline metabolism, with methods used in biochemi...

journal_title：Journal of clinical pathology

authors： Barron J

更新日期：2010-08-01 00:00:00

abstract：AIMS:Glypican 3 (GPC3) is a heparan sulphate proteoglycan that shows elevated levels in the serum of patients with hepatocellular carcinoma (HCC), but not in healthy blood donors or patients with benign liver disease. This study explores the value of GPC3 expression for diagnosis of HCC by immunohistochemistry in liver...

journal_title：Journal of clinical pathology

authors： Wang FH,Yip YC,Zhang M,Vong HT,Chan KI,Wai KC,Wen JM

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Some uterine endometrioid adenocarcinomas exhibit a distinctive morphological phenotype characterised by the formation of microcystic, elongated and fragmented (MELF) glands. Immunohistochemical studies have suggested that MELF-type changes represent an epithelial-mesenchymal transition which has been associ...

journal_title：Journal of clinical pathology

authors： Stewart CJ,Amanuel B,Grieu F,Carrello A,Iacopetta B

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Laboratories traditionally culture toxoplasma tachyzoites in animals for testing and experimental use. This article considers why available cell culture methods are not used more often. AIM:To compare HeLa cell culture and animal culture for production of toxoplasma tachyzoites. METHODS:In 2000 HeLa cultur...

journal_title：Journal of clinical pathology

authors： Chatterton JM,McDonagh S,Ho-Yen DO

更新日期：2010-05-01 00:00:00

abstract：:The Human Leukocyte Antigen (HLA) system plays a critical role in regulating the immune response. As a consequence of its role in immune regulation and exquisite polymorphism, the HLA system also constitutes an immunological barrier which must be avoided or otherwise overcome in clinical transplantation. This introduc...

journal_title：Journal of clinical pathology

authors： Howell WM,Carter V,Clark B

更新日期：2010-05-01 00:00:00

abstract：:A 43-year-old man, admitted with a swollen right thigh, was diagnosed with a deep vein thrombosis. On day 6 he became septic. A CT scan demonstrated a right-sided hydronephrosis and a large retroperitoneal collection. Blood cultures and perinephric pus grew Escherichia coli resistant to amoxicillin only. On day 12 a v...

journal_title：Journal of clinical pathology

authors： Alleyne SA,Bukhari SS,Fraser M,Spiers P

更新日期：2010-04-01 00:00:00

abstract：:Platelet transfusions have the highest incidence of post-transfusion sepsis compared with any other blood products. Recent reports suggest that platelet-related bacteraemia occurs at a frequency of approximately 50 times greater than that for red blood cells. The source is usually skin contaminants from the donor and ...

journal_title：Journal of clinical pathology

authors： Coutinho H,Galloway A,Ajdukiewicz K,Cleeve V

更新日期：2010-03-01 00:00:00

abstract：:Assessment of ERBB2 (HER2) status in breast carcinomas has become critical in determining response to the humanised monoclonal antibody trastuzumab. The current joint College of American Pathologists and the American Society of Clinical Oncology guidelines for the evaluation of HER2 status in breast carcinoma involve ...

journal_title：Journal of clinical pathology

authors： Gruver AM,Peerwani Z,Tubbs RR

更新日期：2010-03-01 00:00:00

abstract：:Gastroblastoma is a rare gastric epitheliomesenchymal biphasic tumour composed of spindle and epithelial cells, reported by Miettinen et al in a series of three cases in 2009. All those cases arose in stomachs of young adults. Neither the epithelial nor the mesenchymal component displayed sufficient atypia to diagnose...

journal_title：Journal of clinical pathology

authors： Shin DH,Lee JH,Kang HJ,Choi KU,Kim JY,Park DY,Lee CH,Sol MY,Park JH,Kim HY,Montgomery E

更新日期：2010-03-01 00:00:00

abstract：:A histological diagnosis of pT4 stage is used as the basis for offering adjuvant therapy to patients with colorectal cancer. Histological features diagnostic of pT4 stage in colorectal cancer include: (1) presence of tumour perforation, (2) invasion of an adjacent organ, (3) direct or discontinuous tumour extending to...

journal_title：Journal of clinical pathology

authors： Swamy R

更新日期：2010-02-01 00:00:00